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Our Science – Pavlakis Website

George N. Pavlakis, M.D., Ph.D.

Selected Publications

1)  Felber BK, Hadzopoulou-Cladaras M, Cladaras C, Copeland T, Pavlakis GN.
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.
Proc. Natl. Acad. Sci. U.S.A. 86: 1495-9, 1989.
[Journal]
2)  Schwartz S, Campbell M, Nasioulas G, Harrison J, Felber BK, Pavlakis GN.
Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression.
J. Virol. 66: 7176-82, 1992.
[Journal]
3)  Templeton NS, Lasic DD, Frederik PM, Strey HH, Roberts DD, Pavlakis GN.
Improved DNA: liposome complexes for increased systemic delivery and gene expression.
Nat. Biotechnol. 15: 647-52, 1997.
[Journal]
4)  Bergamaschi C, Bear J, Rosati M, Kelly Beach R, Alicea C, Sowder R, Chertova E, Rosenberg SA, Felber BK, Pavlakis GN.
Circulating interleukin-15 (IL-15) exists as heterodimeric complex with soluble IL-15 receptor alpha (IL-15Rα) in human serum.
Blood. 120: e1-8, 2012.
[Journal]
5)  Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, von Gegerfelt A, Huang W, Guan Y, Keele BF, Bess JW, Piatak M, Lifson JD, Williams WT, Shen X, Tomaras GD, Amara RR, Robinson HL, Johnson W, Broderick KE, Sardesai NY, Venzon DJ, Hirsch VM, Felber BK, Pavlakis GN.
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.
Proc. Natl. Acad. Sci. U.S.A. 110: 2975-80, 2013.
[Journal]
6)  Kulkarni V, Valentin A, Rosati M, Alicea C, Singh AK, Jalah R, Broderick KE, Sardesai NY, Le Gall S, Mothe B, Brander C, Rolland M, Mullins JI, Pavlakis GN, Felber BK.
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
PLoS ONE. 9: e86254, 2014.
[Journal]
7)  Jalah R, Kulkarni V, Patel V, Rosati M, Alicea C, Bear J, Yu L, Guan Y, Shen X, Tomaras GD, LaBranche C, Montefiori DC, Prattipati R, Pinter A, Bess J, Lifson JD, Reed SG, Sardesai NY, Venzon DJ, Valentin A, Pavlakis GN, Felber BK.
DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques.
PLoS ONE. 9: e91550, 2014.
[Journal]
8)  Kulkarni V, Rosati M, Jalah R, Ganneru B, Alicea C, Yu L, Guan Y, Labranche C, Montefiori DC, King AD, Valentin A, Pavlakis GN, Felber BK.
DNA vaccination by intradermal electroporation induces long-lasting immune responses in rhesus macaques.
J. Med. Primatol. [Epub ahead of print], 2014.
[Journal]
9)  Vargas-Inchaustegui DA, Tuero I, Mohanram V, Musich T, Pegu P, Valentin A, Sui Y, Rosati M, Bear J, Venzon DJ, Kulkarni V, Alicea C, Pilkington GR, Liyanage NP, Demberg T, Gordon SN, Wang Y, Hogg AE, Frey B, Patterson LJ, DiPasquale J, Montefiori DC, Sardesai NY, Reed SG, Berzofsky JA, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M.
Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.
Clin. Immunol. [Epub ahead of print], 2014.
[Journal]
10)  Vaccari M, Halwani R, Patterson LJ, Boasso A, Beal J, Tryniszewska E, Hryniewicz A, Venzon D, Haddad EK, El-Far M, Rosati M, Pavlakis GN, Felber BK, Al-Muhsen S, Robert-Guroff M, Sekaly RP, Franchini G.
Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS.
J. Virol. 87: 3526-37, 2013.
[Journal]
11)  Chertova E, Bergamaschi C, Chertov O, Sowder R, Bear J, Roser JD, Beach RK, Lifson JD, Felber BK, Pavlakis GN.
Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15{middle dot}IL-15Ra Cytokine Compared to IL-15 Monomer.
J. Biol. Chem. 288: 18093-103, 2013.
[Journal]
12)  Kulkarni V, Rosati M, Bear J, Pilkington GR, Jalah R, Bergamaschi C, Singh AK, Alicea C, Chowdhury B, Zhang G, Kim E, Wolinsky SM, Huang W, Guan Y, Labranche C, Montefiori DC, Broderick KE, Sardesai NY, Valentin A, Felber BK, Pavlakis GN.
Comparison of intradermal and intramuscular delivery followed in vivo electroporation of SIV Env DNA in macaques.
Hum Vaccin Immunother. 9: 2081-94, 2013.
[Journal]
13)  Kulkarni V, Rosati M, Valentin A, Ganneru B, Singh AK, Yan J, Rolland M, Alicea C, Beach RK, Zhang GM, Le Gall S, Broderick KE, Sardesai NY, Heckerman D, Mothe B, Brander C, Weiner DB, Mullins JI, Pavlakis GN, Felber BK.
HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice.
PLoS ONE. 8: e60245, 2013.
[Journal]
14)  Li J, Valentin A, Kulkarni V, Rosati M, Beach RK, Alicea C, Hannaman D, Reed SG, Felber BK, Pavlakis GN.
HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques.
Vaccine. 31: 3747-55, 2013.
[Journal]
15)  Virnik K, Hockenbury M, Ni Y, Beren J, Pavlakis GN, Felber BK, Berkower I.
Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques.
Retrovirology. 10: 99, 2013.
[Journal]
16)  Vaccari M, Keele BF, Bosinger SE, Doster MN, Ma ZM, Pollara J, Hryniewicz A, Ferrari G, Guan Y, Forthal DN, Venzon D, Fenizia C, Morgan T, Montefiori D, Lifson JD, Miller CJ, Silvestri G, Rosati M, Felber BK, Pavlakis GN, Tartaglia J, Franchini G.
Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure.
J. Virol. 87: 3538-48, 2013.
[Journal]
17)  Lindsay RW, Ouellette I, Arendt HE, Martinez J, DeStefano J, Lopez M, Pavlakis GN, Chiuchiolo MJ, Parks CL, King CR.
SIV antigen-specific effects on immune responses induced by vaccination with DNA electroporation and plasmid IL-12.
Vaccine. 31: 4749-58, 2013.
[Journal]
18)  Jalah R, Rosati M, Ganneru B, Pilkington GR, Valentin A, Kulkarni V, Bergamaschi C, Chowdhury B, Zhang GM, Beach RK, Alicea C, Broderick KE, Sardesai NY, Pavlakis GN, Felber BK.
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
J. Biol. Chem. 288: 6763-76, 2013.
[Journal]
19)  Kulkarni V, Rosati M, Valentin A, Jalah R, Alicea C, Yu L, Guan Y, Shen X, Tomaras GD, Labranche C, Montefiori DC, Irene C, Prattipati R, Pinter A, Sullivan SM, Pavlakis GN, Felber BK.
Vaccination with Vaxfectin (®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.
Hum Vaccin Immunother. 9: 2069-80, 2013.
[Journal]
20)  Ng SS, Li A, Pavlakis GN, Ozato K, Kino T.
Viral infection increases glucocorticoid-induced interleukin-10 production through ERK-mediated phosphorylation of the glucocorticoid receptor in dendritic cells: potential clinical implications.
PLoS ONE. 8: e63587, 2013.
[Journal]
21)  Mothe B, Llano A, Ibarrondo J, Zamarreño J, Schiaulini M, Miranda C, Ruiz-Riol M, Berger CT, Herrero MJ, Palou E, Plana M, Rolland M, Khatri A, Heckerman D, Pereyra F, Walker BD, Weiner D, Paredes R, Clotet B, Felber BK, Pavlakis GN, Mullins JI, Brander C.
CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control.
PLoS ONE. 7: e29717, 2012.
[Journal]
22)  Jalah R, Patel V, Kulkarni V, Rosati M, Alicea C, Ganneru B, von Gegerfelt A, Huang W, Guan Y, Broderick KE, Sardesai NY, Labranche C, Montefiori DC, Pavlakis GN, Felber BK.
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
Hum Vaccin Immunother. 8: 1620-9, 2012.
[Journal]
23)  Lai L, Kwa SF, Kozlowski PA, Montefiori DC, Nolen TL, Hudgens MG, Johnson WE, Ferrari G, Hirsch VM, Felber BK, Pavlakis GN, Earl PL, Moss B, Amara RR, Robinson HL.
SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses.
Vaccine. 30: 1737-45, 2012.
[Journal]
24)  Winstone N, Wilson AJ, Morrow G, Boggiano C, Chiuchiolo MJ, Lopez M, Kemelman M, Ginsberg AA, Mullen K, Coleman JW, Wu CD, Narpala S, Ouellette I, Dean HJ, Lin F, Sardesai NY, Cassamasa H, McBride D, Felber BK, Pavlakis GN, Schultz A, Hudgens MG, King CR, Zamb TJ, Parks CL, McDermott AB.
Enhanced Control of Pathogenic Simian Immunodeficiency Virus SIVmac239 Replication in Macaques Immunized with an Interleukin-12 Plasmid and a DNA Prime-Viral Vector Boost Vaccine Regimen.
J. Virol. 85: 9578-87, 2011.
[Journal]
25)  Strbo N, Vaccari M, Pahwa S, Kolber MA, Fisher E, Gonzalez L, Doster MN, Hryniewicz A, Felber BK, Pavlakis GN, Franchini G, Podack ER.
Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa.
Vaccine. 29: 2619-25, 2011.
[Journal]
26)  Majerciak V, Uranishi H, Kruhlak M, Pilkington GR, Massimelli MJ, Bear J, Pavlakis GN, Felber BK, Zheng ZM.
Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.
J. Virol. 85: 1528-40, 2011.
[Journal]
27)  Vercruysse T, Pawar S, De Borggraeve W, Pardon E, Pavlakis GN, Pannecouque C, Steyaert J, Balzarini J, Daelemans D.
Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.
RNA Biol. 8: 316-24, 2011.
[Journal]
28)  Niu L, Termini JM, Kanagavelu SK, Gupta S, Rolland MM, Kulkarni V, Pavlakis GN, Felber BK, Mullins JI, Fischl MA, Stone GW.
Preclinical evaluation of HIV-1 therapeutic ex vivo dendritic cell vaccines expressing consensus Gag antigens and conserved Gag epitopes.
Vaccine. 29: 2110-9, 2011.
[Journal]
29)  Kulkarni V, Jalah R, Ganneru B, Bergamaschi C, Alicea C, von Gegerfelt A, Patel V, Zhang G, Chowdhury B, Broderick KE, Sardesai NY, Valentin A, Rosati M, Felber BK, Pavlakis GN.
Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.
Vaccine. 29: 6742-54, 2010.
[Journal]
30)  Minang JT, Trivett MT, Bolton DL, Trubey CM, Estes JD, Li Y, Smedley J, Pung R, Rosati M, Jalah R, Pavlakis GN, Felber BK, Piatak M, Roederer M, Lifson JD, Ott DE, Ohlen C.
Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones in rhesus macaques during acute infection.
J. Immunol. 184: 315-26, 2010.
[Journal]
31)  von Gegerfelt A, Valentin A, Alicea C, Van Rompay KK, Marthas ML, Montefiori DC, Pavlakis GN, Felber BK.
Emergence of Simian Immunodeficiency Virus-Specific Cytotoxic CD4+ T Cells and Increased Humoral Responses Correlate with Control of Rebounding Viremia in CD8-Depleted Macaques Infected with Rev-Independent Live-Attenuated Simian Immunodeficiency Virus.
J Immunol. 185: 3348-58, 2010.
[Journal]
32)  Valentin A, Morrow M, Poirier RH, Aleman K, Little R, Yarchoan R, Pavlakis GN.
Identification of a potential pharmacological sanctuary for HIV type 1 in a fraction of CD4(+) primary cells.
AIDS Res. Hum. Retroviruses. 26: 79-88, 2010.
[Journal]
33)  Patel V, Valentin A, Kulkarni V, Rosati M, Bergamaschi C, Jalah R, Alicea C, Minang JT, Trivett MT, Ohlen C, Zhao J, Robert-Guroff M, Khan AS, Draghia-Akli R, Felber BK, Pavlakis GN.
Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization.
Vaccine. 28: 4827-36, 2010.
[Journal]
34)  Santra S, Liao HX, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A, Quinn D, Parks RJ, Tsao CY, Carville A, Mansfield KG, Pavlakis GN, Felber BK, Haynes BF, Korber BT, Letvin NL.
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.
Nat. Med. 16: 324-8, 2010.
[Journal]
35)  Witko SE, Johnson JE, Kalyan NK, Felber BK, Pavlakis GN, Sidhu MK, Hendry RM, Udem SA, Parks CL.
Refined methods for propagating vesicular stomatitis virus vectors that are defective for G protein expression.
J. Virol. Methods. 164: 43-50, 2010.
[Journal]
36)  Valentin A, von Gegerfelt A, Rosati M, Miteloudis G, Alicea C, Bergamaschi C, Jalah R, Patel V, Khan AS, Draghia-Akli R, Pavlakis GN, Felber BK.
Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit.
Vaccine. 28: 1962-74, 2010.
[Journal]
37)  Legiewicz M, Zolotukhin AS, Pilkington GR, Purzycka KJ, Mitchell M, Uranishi H, Bear J, Pavlakis GN, Le Grice SF, Felber BK.
The RNA transport element of the murine musD retrotransposon requires long-range intramolecular interactions for function.
J. Biol. Chem. 285: 42097-104, 2010.
[Journal]
38)  Valentin A, Chikhlikar P, Patel V, Rosati M, Maciel M, Chang KH, Silvera P, Felber BK, Pavlakis GN, August JT, Marques ET.
Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes.
Vaccine. 27: 4840-9, 2009.
[Journal]
39)  Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA.
Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.
J. Immunol. 183: 1120-32, 2009.
[Journal]
40)  Rosati M, Bergamaschi C, Valentin A, Kulkarni V, Jalah R, Alicea C, Patel V, von Gegerfelt AS, Montefiori DC, Venzon DJ, Khan AS, Draghia-Akli R, Van Rompay KK, Felber BK, Pavlakis GN.
DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge.
Proc. Natl. Acad. Sci. U.S.A. 106: 15831-6, 2009.
[Journal]
41)  Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, Khan T, Dai RM, Scheetz L, Lincoln E, Back TC, Powell D, Hurwitz AA, Sayers TJ, Kastelein R, Pavlakis GN, Felber BK, Trinchieri G, Wigginton JM.
Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.
J. Immunol. 182: 4328-38, 2009.
[Journal]
42)  Zolotukhin AS, Uranishi H, Lindtner S, Bear J, Pavlakis GN, Felber BK.
Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA.
Nucleic Acids Res. 37: 7151-62, 2009.
[Journal]
43)  Bergamaschi C, Jalah R, Kulkarni V, Rosati M, Zhang GM, Alicea C, Zolotukhin AS, Felber BK, Pavlakis GN.
Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo.
J. Immunol. 183: 3064-72, 2009.
[Journal]
44)  Uranishi H, Zolotukhin AS, Lindtner S, Warming S, Zhang GM, Bear J, Copeland NG, Jenkins NA, Pavlakis GN, Felber BK.
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
J. Biol. Chem. 284: 26106-16, 2009.
[Journal]
45)  Morrow M, Valentin A, Little R, Yarchoan R, Pavlakis GN.
A splenic marginal zone-like peripheral blood CD27+B220- B cell population is preferentially depleted in HIV type 1-infected individuals.
AIDS Res. Hum. Retroviruses. 24: 621-33, 2008.
[Journal]
46)  Zeng H, Horie K, Madisen L, Pavlova MN, Gragerova G, Rohde AD, Schimpf BA, Liang Y, Ojala E, Kramer F, Roth P, Slobodskaya O, Dolka I, Southon EA, Tessarollo L, Bornfeldt KE, Gragerov A, Pavlakis GN, Gaitanaris GA.
An inducible and reversible mouse genetic rescue system.
PLoS Genet. 4: e1000069, 2008.
[Journal]
47)  Vaccari M, Boasso A, Ma Z, Cecchinato V, Venzon D, Doster MN, Tsai WP, Shearer GM, Fuchs D, Felber BK, Pavlakis GN, Miller CJ, Franchini G.
CD4+ T-cell loss and delayed expression of modulators of immune responses at mucosal sites of vaccinated macaques following SIV(mac251) infection.
Mucosal Immunol. 1: 497-507, 2008.
[Journal]
48)  Xu R, Megati S, Roopchand V, Luckay A, Masood A, Garcia-Hand D, Rosati M, Weiner DB, Felber BK, Pavlakis GN, Sidhu MK, Eldridge JH, Egan MA.
Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines.
Vaccine. 26: 4819-29, 2008.
[Journal]
49)  Rosati M, Valentin A, Jalah R, Patel V, von Gegerfelt A, Bergamaschi C, Alicea C, Weiss D, Treece J, Pal R, Markham PD, Marques ET, August JT, Khan A, Draghia-Akli R, Felber BK, Pavlakis GN.
Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation.
Vaccine. 26: 5223-9, 2008.
[Journal]
50)  Bergamaschi C, Rosati M, Jalah R, Valentin A, Kulkarni V, Alicea C, Zhang GM, Patel V, Felber BK, Pavlakis GN.
Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.
J. Biol. Chem. 283: 4189-99, 2008.
[Journal]
51)  Megati S, Garcia-Hand D, Cappello S, Roopchand V, Masood A, Xu R, Luckay A, Chong SY, Rosati M, Sackitey S, Weiner DB, Felber BK, Pavlakis GN, Israel ZR, Smith LR, Eldridge JH, Sidhu MK, Egan MA.
Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses.
Vaccine. 26: 5083-94, 2008.
[Journal]
52)  Zolotukhin AS, Schneider R, Uranishi H, Bear J, Tretyakova I, Michalowski D, Smulevitch S, O'Keeffe S, Pavlakis GN, Felber BK.
The RNA transport element RTE is essential for IAP LTR-retrotransposon mobility.
Virology. 377: 88-99, 2008.
[Journal]
53)  Halwani R, Boyer JD, Yassine-Diab B, Haddad EK, Robinson TM, Kumar S, Parkinson R, Wu L, Sidhu MK, Phillipson-Weiner R, Pavlakis GN, Felber BK, Lewis MG, Shen A, Siliciano RF, Weiner DB, Sekaly RP.
Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques.
J. Immunol. 180: 7969-7979, 2008.
[Journal]
54)  Chong SY, Egan MA, Kutzler MA, Megati S, Masood A, Roopchard V, Garcia-Hand D, Montefiori DC, Quiroz J, Rosati M, Schadeck EB, Boyer JD, Pavlakis GN, Weiner DB, Sidhu M, Eldridge JH, Israel ZR.
Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.
Vaccine. 25: 4967-82, 2007.
[Journal]
55)  Luckay A, Sidhu MK, Kjeken R, Megati S, Chong SY, Roopchand V, Garcia-Hand D, Abdullah R, Braun R, Montefiori DC, Rosati M, Felber BK, Pavlakis GN, Mathiesen I, Israel ZR, Eldridge JH, Egan MA.
Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques.
J. Virol. 81: 5257-69, 2007.
[Journal]
56)  Jalah R, Rosati M, Kulkarni V, Patel V, Bergamaschi C, Valentin A, Zhang GM, Sidhu MK, Eldridge JH, Weiner DB, Pavlakis GN, Felber BK.
Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids.
DNA Cell Biol. 26: 827-40, 2007.
[Journal]
57)  Gragerov A, Horie K, Pavlova M, Madisen L, Zeng H, Gragerova G, Rhode A, Dolka I, Roth P, Ebbert A, Moe S, Navas C, Finn E, Bergmann J, Vassilatis DK, Pavlakis GN, Gaitanaris GA.
Large-scale, saturating insertional mutagenesis of the mouse genome.
Proc. Natl. Acad. Sci. U.S.A. 104: 14406-11, 2007.
[Journal]
58)  von Gegerfelt AS, Rosati M, Alicea C, Valentin A, Roth P, Bear J, Franchini G, Albert PS, Bischofberger N, Boyer JD, Weiner DB, Markham P, Israel ZR, Eldridge JH, Pavlakis GN, Felber BK.
Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.
J. Virol. 81: 1972-9, 2007.
[Journal]
59)  Robinson TM, Sidhu MK, Pavlakis GN, Felber BK, Silvera P, Lewis MG, Eldridge J, Weiner DB, Boyer JD.
Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses.
J. Med. Primatol. 36: 276-84, 2007.
[Journal]
60)  Felber BK, Zolotukhin AS, Pavlakis GN.
Posttranscriptional Control of HIV-1 and Other Retroviruses and Its Practical Applications.
Adv. Pharmacol. 55: 161-97, 2007.
[Journal]
61)  Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, Waldmann TA, Eldridge J, Weiner DB.
Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.
Proc. Natl. Acad. Sci. U.S.A. 104: 18648-53, 2007.
[Journal]
62)  Schadeck EB, Sidhu M, Egan MA, Chong SY, Piacente P, Masood A, Garcia-Hand D, Cappello S, Roopchand V, Megati S, Quiroz J, Boyer JD, Felber BK, Pavlakis GN, Weiner DB, Eldridge JH, Israel ZR.
A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques.
Vaccine. 24: 4677-87, 2006.
[Journal]
63)  Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, Bronson RT, Lifson JD, Rosati M, Pavlakis GN, Felber BK, Knipe DM, Desrosiers RC.
Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.
Virology. 357: 199-214, 2006.
[Journal]
64)  Kumar S, Yan J, Muthumani K, Ramanathan MP, Yoon H, Pavlakis GN, Felber BK, Sidhu M, Boyer JD, Weiner DB.
Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct.
DNA Cell Biol. 25: 383-92, 2006.
[Journal]
65)  Hel Z, Tsai WP, Tryniszewska E, Nacsa J, Markham PD, Lewis MG, Pavlakis GN, Felber BK, Tartaglia J, Franchini G.
Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genes.
J. Immunol. 176: 85-96, 2006.
[Journal]
66)  von Gegerfelt AS, Alicea C, Valentin A, Morrow M, van Rompay KK, Ayash-Rashkovsky M, Markham P, Else JG, Marthas ML, Pavlakis GN, Ruprecht RM, Felber BK.
Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques.
AIDS Res. Hum. Retroviruses. 22: 516-28, 2006.
[Journal]
67)  Watanabe D, Brockman MA, Ndung'u T, Mathews L, Lucas WT, Murphy CG, Felber BK, Pavlakis GN, Deluca NA, Knipe DM.
Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.
Virology. 357: 186-98, 2006.
[Journal]
68)  Egan MA, Megati S, Roopchand V, Garcia-Hand D, Luckay A, Chong SY, Rosati M, Sackitey S, Weiner DB, Felber BK, Pavlakis GN, Israel ZR, Eldridge JH, Sidhu MK.
Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice.
Vaccine. 24: 4510-23, 2006.
[Journal]
69)  Lindtner S, Zolotukhin AS, Uranishi H, Bear J, Kulkarni V, Smulevitch S, Samiotaki M, Panayotou G, Felber BK, Pavlakis GN.
RBM15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.
J Biol Chem. 281: 36915-28, 2006.
[Journal]
70)  Smulevitch S, Bear J, Alicea C, Rosati M, Jalah R, Zolotukhin AS, von Gegerfelt A, Michalowski D, Moroni C, Pavlakis GN, Felber BK.
RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs.
Retrovirology. 3: 6, 2006.
[Journal]
71)  Daelemans D, Pannecouque C, Pavlakis GN, Tabarrini O, De Clercq E.
A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors.
Mol Pharmacol. 67: 1574-80, 2005.
[Journal]
72)  Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB.
Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.
J Immunol. 175: 112-23, 2005.
[Journal]
73)  Boyer JD, Robinson TM, Maciag PC, Peng X, Johnson RS, Pavlakis G, Lewis MG, Shen A, Siliciano R, Brown CR, Weiner DB, Paterson Y.
DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication.
Virology. 333: 88-101, 2005.
[Journal]
74)  Rosati M, von Gegerfelt A, Roth P, Alicea C, Valentin A, Robert-Guroff M, Venzon D, Montefiori DC, Markham P, Felber BK, Pavlakis GN.
DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.
J Virol. 79: 8480-92, 2005.
[Journal]
75)  Daelemans D, Costes SV, Lockett S, Pavlakis GN.
Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo.
Mol Cell Biol. 25: 728-39, 2005.
[Journal]
76)  Egan MA, Chong SY, Megati S, Montefiori DC, Rose NF, Boyer JD, Sidhu MK, Quiroz J, Rosati M, Schadeck EB, Pavlakis GN, Weiner DB, Rose JK, Israel ZR, Udem SA, Eldridge JH.
Priming with Plasmid DNAs Expressing Interleukin-12 and Simian Immunodeficiency Virus Gag Enhances the Immunogenicity and Efficacy of an Experimental AIDS Vaccine Based on Recombinant Vesicular Stomatitis Virus.
AIDS Res Hum Retroviruses. 21: 629-43, 2005.
[Journal]
77)  Boyer JD, Robinson TM, Kutzler MA, Parkinson R, Calarota SA, Sidhu MK, Muthumani K, Lewis M, Pavlakis G, Felber B, Weiner D.
SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques.
J. Med. Primatol. 34: 262-70, 2005.
[Journal]
78)  Smulevitch S, Michalowski D, Zolotukhin AS, Schneider R, Bear J, Roth P, Pavlakis GN, Felber BK.
Structural and functional analysis of the RNA transport element, a member of an extensive family present in the mouse genome.
J Virol. 79: 2356-65, 2005.
[Journal]
79)  Yuste E, Johnson W, Pavlakis GN, Desrosiers RC.
Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virus.
J. Virol. 79: 12455-63, 2005.
[Journal]
80)  Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Erwin-Cohen R, Chrousos GP, Pavlakis GN.
Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.
J Virol. 79: 2780-7, 2005.
[Journal]
81)  Lueders KK, De Rosa SC, Valentin A, Pavlakis GN, Roederer M, Hamer DH.
A potent anti-HIV immunotoxin blocks spreading infection by primary HIV type 1 isolates in multiple cell types.
AIDS Res Hum Retroviruses. 20: 145-50, 2004.
[Journal]
82)  Costes SV, Daelemans D, Cho EH, Dobbin Z, Pavlakis G, Lockett S.
Automatic and quantitative measurement of protein-protein colocalization in live cells.
Biophys J. 86: 3993-4003, 2004.
[Journal]
83)  Daelemans D, Costes SV, Cho EH, Erwin-Cohen RA, Lockett S, Pavlakis GN.
In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm by fluorescence resonance energy transfer.
J Biol Chem. 279: 50167-75, 2004.
[Journal]
84)  Kino T, Pavlakis GN.
Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.
DNA Cell Biol. 23: 193-205, 2004.
[Journal]
85)  Otero M, Calarota SA, Felber B, Laddy D, Pavlakis G, Boyer JD, Weiner DB.
Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model.
Vaccine. 22: 1782-90, 2004.
[Journal]
86)  Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Erwin-Cohen R, Chrousos GP, Pavlakis GN.
Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.
J Virol. 79: 2780-7, 2004.
[Journal]
87)  Fitzgerald JC, Gao GP, Reyes-Sandoval A, Pavlakis GN, Xiang ZQ, Wlazlo AP, Giles-Davis W, Wilson JM, Ertl HC.
A simian replication-defective adenoviral recombinant vaccine to HIV-1 gag.
J Immunol. 170: 1416-22, 2003.
[Journal]
88)  Zhao J, Lou Y, Pinczewski J, Malkevitch N, Aldrich K, Kalyanaraman VS, Venzon D, Peng B, Patterson LJ, Edghill-Smith Y, Woodward R, Pavlakis GN, Robert-Guroff M.
Boosting of SIV-specific immune responses in rhesus macaques by repeated administration of Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinants.
Vaccine. 21: 4022-35, 2003.
[Journal]
89)  Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN, Jenkins NA, Copeland NG.
Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein.
Blood. 101: 1934-40, 2003.
[Journal]
90)  Zhao J, Pinczewski J, Gómez-Román VR, Venzon D, Kalyanaraman VS, Markham PD, Aldrich K, Moake M, Montefiori DC, Lou Y, Pavlakis GN, Robert-Guroff M.
Improved protection of rhesus macaques against intrarectal simian immunodeficiency virus SIV(mac251) challenge by a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen.
J Virol. 77: 8354-65, 2003.
[Journal]
91)  Valentin A, Pavlakis GN.
Natural killer cells are persistently infected and resistant to direct killing by HIV-1.
Anticancer Res. 23: 2071-5, 2003.
[Journal]
92)  Patterson LJ, Malkevitch N, Pinczewski J, Venzon D, Lou Y, Peng B, Munch C, Leonard M, Richardson E, Aldrich K, Kalyanaraman VS, Pavlakis GN, Robert-Guroff M.
Potent, persistent induction and modulation of cellular immune responses in rhesus macaques primed with Ad5hr-simian immunodeficiency virus (SIV) env/rev, gag, and/or nef vaccines and boosted with SIV gp120.
J Virol. 77: 8607-20, 2003.
[Journal]
93)  Calarota SA, Otero M, Hermanstayne K, Lewis M, Rosati M, Felber BK, Pavlakis GN, Boyer JD, Weiner DB.
Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques.
J Immunol Methods. 279: 55-67, 2003.
[Journal]
94)  Daelemans D, Afonina E, Nilsson J, Werner G, Kjems J, De Clercq E, Pavlakis GN, Vandamme AM.
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.
Proc Natl Acad Sci U S A. 99: 14440-5, 2002.
[Journal]
95)  Hel Z, Nacsa J, Tryniszewska E, Tsai WP, Parks RW, Montefiori DC, Felber BK, Tartaglia J, Pavlakis GN, Franchini G.
Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses.
J Immunol. 169: 4778-87, 2002.
[Journal]
96)  Kino T, Gragerov A, Slobodskaya O, Tsopanomichalou M, Chrousos GP, Pavlakis GN.
Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.
J Virol. 76: 9724-34, 2002.
[Journal]
97)  Muthumani K, Kudchodkar S, Zhang D, Bagarazzi ML, Kim JJ, Boyer JD, Ayyavoo V, Pavlakis GN, Weiner DB.
Issues for improving multiplasmid DNA vaccines for HIV-1.
Vaccine. 20: 1999-2003, 2002.
[Journal]
98)  Boyer JD, Chattergoon M, Muthumani K, Kudchodkar S, Kim J, Bagarazzi M, Pavlakis G, Sekaly R, Weiner DB.
Next generation DNA vaccines for HIV-1.
J Liposome Res. 12: 137-42, 2002.
[Journal]
99)  Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP.
Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex.
J Biol Chem. 277: 2396-405, 2002.
[Journal]
100)  Valentin A, Rosati M, Patenaude DJ, Hatzakis A, Kostrikis LG, Lazanas M, Wyvill KM, Yarchoan R, Pavlakis GN.
Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy.
Proc Natl Acad Sci U S A. 99: 7015-20, 2002.
[Journal]
101)  von Gegerfelt AS, Liska V, Li PL, McClure HM, Horie K, Nappi F, Montefiori DC, Pavlakis GN, Marthas ML, Ruprecht RM, Felber BK.
Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques.
J Virol. 76: 96-104, 2002.
[Journal]
102)  Rosati M, Valentin A, Patenaude DJ, Pavlakis GN.
CCAAT-enhancer-binding protein beta (C/EBP beta) activates CCR5 promoter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals.
J Immunol. 167: 1654-62, 2001.
[Journal]
103)  Nappi F, Schneider R, Zolotukhin A, Smulevitch S, Michalowski D, Bear J, Felber BK, Pavlakis GN.
Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.
J Virol. 75: 4558-69, 2001.
[Journal]
104)  Neumann M, Afonina E, Ceccherini-Silberstein F, Schlicht S, Erfle V, Pavlakis GN, Brack-Werner R.
Nucleocytoplasmic transport in human astrocytes: decreased nuclear uptake of the HIV Rev shuttle protein.
J Cell Sci. 114: 1717-29, 2001.
[Journal]
105)  Kino T, Stauber RH, Resau JH, Pavlakis GN, Chrousos GP.
Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking.
J Clin Endocrinol Metab. 86: 5600-8, 2001.
[Journal]
106)  Hel Z, Tsai WP, Thornton A, Nacsa J, Giuliani L, Tryniszewska E, Poudyal M, Venzon D, Wang X, Altman J, Watkins DI, Lu W, von Gegerfelt A, Felber BK, Tartaglia J, Pavlakis GN, Franchini G.
Potentiation of simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen.
J Immunol. 167: 7180-91, 2001.
[Journal]
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